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Image Search Results
Journal: Molecular imaging and biology
Article Title: An analysis of isoclonal antibody formats suggests a role for measuring PD-L1 with low molecular weight PET radiotracers
doi: 10.1007/s11307-020-01527-3
Figure Lengend Snippet: A summary of the kinetic constants for the C4 minibody, scFv and their respective DFO-conjugates. The binding was assayed against the ectodomain of recombinant human PD-L1 using biolayer interferometry. The data are representative of two independent experiments. In the case of the K D and the K dis for the C4 minibody, the constants approached the limit of detection and the instrument was not capable of reporting error calculations.
Article Snippet: Kinetic constants for the minibody and scFv antibody against human and
Techniques: Binding Assay, Recombinant
Journal: Molecular imaging and biology
Article Title: An analysis of isoclonal antibody formats suggests a role for measuring PD-L1 with low molecular weight PET radiotracers
doi: 10.1007/s11307-020-01527-3
Figure Lengend Snippet: A. DAR and anti-PDL1 immunohistochemistry (co-stained with hematoxylin) of a liver section from a 1 year old female Alb Cre; MYCTg; KRASG12D genetically engineered mouse model of heptacellular carcinoma. Multiple tracer avid foci are detected against the background of normal liver. At right are shown the merged images with the PDL1 immunohistochemistry magnified at 40X in selected fields of view to show the concordance between radiotracer binding and PD-L1 expression in tumor. Additional fields of view and tumor slices are shown in Supplemental Figure 1. B. Biodistribution data showing the uptake of 89Zr-scFv in an orthotopic hepatocellular tumor established from a mouse cell line derived from the Alb Cre; MYCTg; KRASG12D GEM model.
Article Snippet: Kinetic constants for the minibody and scFv antibody against human and
Techniques: Immunohistochemistry, Staining, Binding Assay, Expressing, Derivative Assay